nucleoside phosphorylase การใช้

• Thymidine phosphorylase or pyrimidine-nucleoside phosphorylase adds 2-deoxy-alpha-D-ribose 1-phosphate to thymine, forming thymidine.
• The reaction is catalysed by, pyrimidine-nucleoside phosphorylase,, uridine phosphorylase, and, thymidine phosphorylase.
• The defect is a type of purine nucleoside phosphorylase deficiency with inactive phosphorylase.
• It is formed by the purine nucleoside phosphorylase mediated phosphorolytic cleavage of 5'- deoxy-5'- fluoroadenosine.
• Further work on nucleotide metabolism allowed him to identify nucleoside phosphorylase, a key enzyme in nucleotide salvage pathways.
• "' Purine nucleoside phosphorylase deficiency "', often called "'PNP-deficiency "', is a rare metabolic disorder which results in immunodeficiency.
• The enzyme, purine nucleoside phosphorylase, or PNP, cleans up metabolic debris that would otherwise build up inside the T cells and shut them down.
• "Peripheral " ( or non-thymic ) causes of T cell deficiency include : Purine nucleoside phosphorylase deficiency, hyper IgM syndrome ( in turn including, for example, 1)
• Nucleoside phosphorylase is an enzyme which cleaves a nucleoside by " de novo " synthesis pathway has been interrupted or is non-existent ( as is the case in the brain ).
• Working with Dr . Giblett in 1972, Ammann described the first patient with purine nucleoside phosphorylase deficiency in association with a unique genetic profile that included depressed T-cell immunity with normal levels of immunoglobulins.
• More specifically some of its important reactions include treatments with 2'- deoxyribonucleoside phosphorylase, methyltransferase, or nucleoside phosphorylase, affording the corresponding 5'- phosphate, giving rise to no methylation at its 5-position, or no cleavage of the glycosyl bond in contrast to 5-fluoro-2'- deoxyuridine, respectively.